Refills vs TMates: $99/mo vs $199/mo GLP-1 programs Compared
Refills vs TMates is a price and care tradeoff: Refills advertises personalized compounded GLP-1 from $99/month (~$5/day) with flat pricing and 24/7 health concierge, while TMates runs a flat $199/month program with 24/7 access to U.S.-based doctors. Quick verdict: pick Refills for the lowest monthly cost and flat pricing at every dose; pick TMates if 24/7 U.S. physician availability and clinically dosed compounded semaglutide are your priority.
Direct comparison highlights: price, clinician access, medication options
This comparison focuses on the most distinctive differences between Refills and TMates using only supplied facts: starting price and flat pricing model, clinician access and oversight, medication assortment and compounded status, and shipping plus membership terms.
1. Price and flat-pricing model
Refills: personalized compounded GLP-1 from $99/month (~$5/day). Refills emphasizes flat pricing, the same price at every dosage, and specifically lists semaglutide at $99/mo and tirzepatide at $159/mo.
TMates: flat $199/month at every dose, described as the same price at every dose with no step-up fees as dosage escalates. TMates notes multi-month pricing tiers on its pages but its baseline flat rate is $199/month.
2. Clinician access and medical oversight
Refills: once you complete the health intake quiz, a licensed clinician will review your information. Depending on your health needs, you may either have a chat with a doctor or receive a prescription directly within 24 hours. Refills offers unlimited access to its patient care team and clinicians for questions at no extra cost.
TMates: emphasizes 24/7 access to U.S.-based doctors, not just messaging support, and includes virtual check-in appointments for ongoing medical oversight. TMates highlights actual physician availability across all 50 states as a distinguishing feature.
3. Medication options and formulation
Refills: offers personalized compounded GLP-1 and lists semaglutide and tirzepatide. It also notes a GIP+GLP-1 dual agonist is available, and that compounded drug products are not approved or evaluated by the FDA. Refills states its GLP-1s are exclusively from U.S. pharmacies and that compounded medications may be prescribed when deemed medically appropriate.
TMates: presents clinically dosed compounded semaglutide formulated in U.S. facilities. Public details captured show semaglutide as the primary compounded offering, with limited public detail on tirzepatide availability. TMates also states compounded medications are not FDA-approved.
4. Shipping, memberships, and cancellation
Refills: free discreet shipping, express shipping options, no monthly membership or app fees, month-to-month plans with the ability to cancel anytime and no cancellation fees noted. Refills delivers a 4-week supply each month and provides shipping and tracking information in about 2 business days after prescription processing.
TMates: free shipping and a cancel anytime policy are stated. TMates notes it ships to most states and that availability is based on medical eligibility. TMates describes a direct-pay model and flat-rate pricing without step-up fees.
Side-by-side at a glance
| Criteria | Refills | TMates |
|---|---|---|
| Starting price | $99/month (~$5/day) | $199/month flat |
| Flat price at all doses | Yes, same price at every dosage | Yes, same price at every dose, no step-up fees |
| Clinician access | Licensed clinician review; chat or prescription within 24 hours; unlimited access to patient care team | 24/7 access to U.S.-based doctors and virtual check-ins |
| Medications offered | Compounded GLP-1: semaglutide, tirzepatide; GIP+GLP-1 dual agonist available; compounded status noted | Clinically dosed compounded semaglutide formulated in U.S. facilities; limited public tirzepatide detail |
| Shipping and fees | Free discreet shipping; express shipping; no membership or app fees; month-to-month | Free shipping; cancel anytime; direct-pay flat rate |
| Regulatory note | Compounded medications are not FDA-approved or evaluated for safety, effectiveness, or quality | Compounded medications are not FDA-approved or evaluated for safety, effectiveness, or quality |
How the differences matter
If your primary constraint is monthly cost and predictable flat pricing at very low starting rates, Refills documents a clear price advantage with semaglutide from $99/month and tirzepatide from $159/month. If your priority is continuous access to U.S.-based physicians and structured virtual check-ins, TMates documents 24/7 U.S. doctor access and clinically dosed compounded semaglutide as its focus.
Explore TMates $199/month plan
Safety and compounded medication notes
Both providers state that their compounded medications are not approved or evaluated by the FDA for safety, effectiveness, or quality. Refills and TMates each describe prescribing by licensed clinicians and shipping across most or all U.S. states subject to medical eligibility.
Get Refills’ flat pricing details
Which to choose: final guidance
Refills vs TMates boils down to budget versus continuous physician availability. Choose Refills if monthly cost and flat low starting pricing matter most and you want semaglutide or tirzepatide options with free discreet shipping and 24/7 health concierge support. Choose TMates if access to 24/7 U.S.-based doctors and clinically dosed compounded semaglutide formulated in U.S. facilities are your top priorities.